To investigate the effect of BCL-6 on miR-142-3p/5p expression in CD4+ T cells, we transfected normal CD4+ T cells with the BCL-6 expression plasmid pCMV6-BCL-6 and SLE CD4+ T cells with the BCL-6 interference plasmid pRS-BCL-6. Here, BCL6 is linked to systemic lupus erythematosus.