According to a study, the expression of miR-142-3p/5p was significantly downregulated in SLE CD4+ T cells compared with that in healthy controls, and the overexpression of miR-142-3p/5p in SLE CD4+ T cells decreased IL-10, CD84, and SAP expression; reduced T cell activity; and decreased IgG production.14 However, the molecular mechanism by which miR-142-3p/5p expression in SLE CD4+ T cells is reduced remains to be elucidated. The gene discussed is CD84; the disease is systemic lupus erythematosus.