The expression of miR-142-3p/5p was downregulated significantly in normal CD4+ T cells overexpressing BCL-6 compared with that in the negative control (Fig. 2c), and miR-142-3p/5p expression was upregulated significantly in SLE CD4+ T cells in which BCL-6 expression had been knocked down compared with that in the negative control (Fig. 2d). This evidence concerns the gene CD4 and systemic lupus erythematosus.