Our previous studies have shown that miR-142-3p/5p expression levels are downregulated in CD4+ T cells from SLE patients compared with those in CD4+ T cells from healthy individuals.14 Here, we investigated whether BCL-6 is involved in the molecular mechanism by which the expression of miR-142-3p/5p is reduced in the CD4+ T cells of SLE patients. The gene discussed is CD4; the disease is systemic lupus erythematosus.