CD4 and systemic lupus erythematosus: Recent studies have found that EZH2 plays an important role in T cell plasticity, activation, and differentiation.40–42 EZH2 may participate in the pathogenesis of SLE by epigenetic remodeling and upregulate or downregulate the expression of lupus-related genes.42 Overexpressed EZH2 in SLE CD4+ T cells mediates increased T cell adhesion to endothelial cells by downregulating JAM-A DNA methylation and upregulating its expression.