In addition, the expression levels of miRNA-142-3p/5p in healthy CD4+ T cells after stimulation with the anti-CD3/CD28 antibody showed a decreasing trend, but this decrease was not obvious or statistically significant.14 In this study, we confirmed that the increased expression of BCL-6 strongly increases binding to the miR-142 promoter proximal element and the inhibition of miR-142-3p/5p expression by increasing H3K27me3 levels and reducing H3K9/K14ac levels in SLE CD4+ T cells. Here, CD28 is linked to systemic lupus erythematosus.