APP and Alzheimer disease: To test whether increased Aβ levels also contribute to PV neuron hyperexcitability in vivo, APP/PS1-PV-Cre mice were treated for 6 weeks with NB-360, a potent BACE1 inhibitor that reduces Aβ levels and amyloid pathology and rescues neuronal network and behavioral deficits in mouse models of AD [39–42].