CDH1 and cancer: Decreased CDH1 expression through promoter DNA methylation is frequently detected in many cancers and is associated with poor prognosis.15,16 To evaluate the feasibility of predicting GC relapse using DNA methylation changes within CpG islands at these gene promoters, in the present study, the association between gene methylation and GC metastasis/recurrence was prospectively studied among 198 GC patients without metastasis at the pN0M0 stage at the time of surgical resection.