HMGB1 and cancer: As shown in Fig. 3b and Supplementary Fig. 13a, 4T1 and TC1 cancer cells undergoing ICD upregulated calreticulin (CALR, eat-me signal) expression on the cell surface and secreted high-mobility group box 1 (HMGB1, danger signal) after treatment with MNDV (GEM)35,36,50.