The limited number of supra-carcinoids did not allow to explore aetiological links; however, it is of note that one of them (LNEN005) belonged to a patient with professional exposure to asbestos (which is known to cause mesothelioma)16 (Table 1), and the tumour harboured a splicing BAP1 somatic mutation (a gene frequently altered in mesothelioma)17. This evidence concerns the gene BAP1 and carcinoid tumor.