Most pathways (n = 32, at FDR < 0.1) were enriched in the MDD with hyperphagia subgroup, including pathways related to inflammasomes, apoptosis and cytokine signaling, namely IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-12, and IL-22. Here, CXCL8 is linked to major depressive disorder.