The pathways ‘Reactome immune system’, ‘KEGG JAK-STAT signaling pathway’, and ‘KEGG apoptosis’ are found to be significantly enriched in obesity gene expression analyses48–50 and were strongly attenuated after BMI correction (FDR: 0.034 to 0.453; 0.094 to 0.426; and 0.049 to 0.203, respectively), indicating that these pathways especially show overlap between obesity and depression. Here, SOAT1 is linked to major depressive disorder.