In FLT3-ITD AML cells, both inhibition of CDK1 (35) and knockdown of Cdc25 (36) have been reported to promote differentiation as judged by CD11b expression, morphological changes, and phosphorylation of CCAAT-enhancer–binding protein α, a maturation-promoting transcription factor. This evidence concerns the gene ITGAM and acute myeloid leukemia.