This catabolic pathway is strikingly similar to the recently uncovered mechanism of therapy-induced PML/RARA degradation in acute promyelocytic leukemia and therapy-induced Tax oncoprotein degradation in adult T-cell lymphoma (Lallemand-Breitenbach et al, 2008; Tatham et al, 2008; Sahin et al, 2014c; Dassouki et al, 2015). The gene discussed is CNTN2; the disease is adult T-cell leukemia/lymphoma.