In addition, the multivariate-adjusted OR and 95% CI for breast cancer were higher in the highest DII group (OR = 5.00, 95% CI: 2.32–10.77 in the highest DII category, p for trend <0.0001) compared to those of the lowest tertile group with the ER− and PR− (ER−/PR−) status. This evidence concerns the gene ESR1 and breast cancer.