Regarding up-regulated genes, KEGG classification reveals that up-regulated genes are involved in altered pathways belonging to the p53 signaling pathway (p-value 0.0000254), ECM (extracellular matrix)-receptor interaction (p-value 0.0000254) and pathways in cancer (p-value 0.0935), displayed in Figure 2B. Reactome classification of up-regulated genes reveals their involvement in extracellular matrix organization (p-value 1.74 × 10−12), degradation of the extracellular matrix (p-value 2.6 × 10−10) and collagen degradation (0.0000149), presented in Figure S1B. The gene discussed is TP53; the disease is cancer.