In this line, studies on engineered organotypic microvascular niches established that while a Thrombospondin-1 secretion from endothelial cells induces maintained BCC dormancy, bioactive Periostin and TGF-β1 function as tumor-promoting factors in sprouting neovasculature which further sparks micrometastatic outgrowth [35]. The gene discussed is THBS1; the disease is neoplasm.