THBS1 and neoplasm: This type of tumor with no angiogenic activity produce moderately high amount of the anti-angiogenesis agents TIMP-1 and thrombospondin-1, proposing that the nonangiogenic, microscopic, dormant stage of melanoma might be susceptible to anti-angiogenic treatment years prior to manifestation of malignant disease, or macroscopically detection of anatomical site of a given tumor, by current approaches [101].