TGFB1 and systemic sclerosis: In addition, it is worth noting that previous studies have clearly shown that a myofibroblastic phenotype is inducible in cultured undifferentiated ADSC or ADSC-derived preadipocytes by treatment with TGFβ, which is considered a leading profibrotic orchestrator in SSc pathogenesis through both canonical and non-canonical signaling pathways [1,14,29].