TGFB1 and systemic sclerosis: In fact, similarly to stimulation with recombinant human TGFβ1, 96-h treatment with SSc sera was able to fully promote the acquisition of a myofibroblast-like contractile phenotype, as demonstrated by a significant reduction in collagen gel area (p < 0.001 vs. basal and healthy serum-treated ADSC) (Figure 4A,B).