Focusing on adipose tissue cells, both ADSC isolated from the abdominal fat of SSc patients and ADSC harvested from bleomycin-treated mice were found to display an anti-adipogenic/profibrotic phenotype, including a reduced capacity for adipogenic differentiation and an increased expression of the myofibroblast marker α-SMA respect to healthy ADSC [29]. The gene discussed is ACTA1; the disease is systemic sclerosis.