Moreover, mRNA levels of Ifnβ, Ifnλ2/3, Irf7, Mx1, Trim12c, Trim21, and Il18 were highly induced in IECs with MOI = 1 or 5 infections but was decreased with MOI = 10, as seen in Figure 5B–H, implying modulation of host antiviral or inflammation responses by high titers of AiV. Here, TRIM21 is linked to infection.