PR+, HER2+/−, Ki67+), (iii) HER2 enriched (ER−, PR−, HER2+), (iv) basal-like subtype (ER−, PR−, HER2−, triple negative; associated with poor prognosis and early onset of metastasis) and (v) claudin-low tumor subtype which is commonly classified as basal-like (or normal breast-like) [8,9,10,11]. This evidence concerns the gene ESR1 and neoplasm.