ESR1 and breast cancer: Strikingly, the discriminant gene analysis performed for chromosomes 13 and 3 also identified specific genes on chromosome 13 (DNAJC15, SPG20, SLITRK6 and DACH1) that had significant overlap in GSEA with genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [Gene ID = 2099] compared to the parental MCF-7 cells, which do [72], (p-value 1.6 × 10−5).