As shown in Figure S1A, the median Gal-9 levels of BRRA and RA patients who smoked was 2286 and 1908 pg/mL, respectively, which showed a statistically significant positive correlation with DAS-28 (r2 0.5043; p = 0.0017) as shown Figure 1D. This evidence concerns the gene LGALS9 and rheumatoid arthritis.