Zhang et al. showed that P-element induced wimpy testis-like (PIWIL)-2 stabilizes HDAC3 by inhibiting E3 ubiquitin-ligase seven in absentia homolog 2 -mediated degradation through casein kinase 2-mediated HDAC3 phosphorylation, thereby accelerating the proliferation of p53-positive cancer cells, followed by a decrease in p21 expression [35]. Here, HDAC3 is linked to cancer.