EGF and breast carcinoma: In MDA-MB-468 human breast cancer cells, the overexpression of c-Src results in the increase in the phosphorylation of EGFRY845, and cells transiently expressing EGFR with Y845F mutation show EGF-induced inhibition of DNA synthesis [12], indicating that c-Src-mediated EGFR phosphorylation is critical for receptor function and breast cancer cell survival.