DVL2 and colorectal carcinoma: Yuan et al. demonstrated in a CRC mouse model that mutation of the histone methyltransferase SETD2 slows down transcription elongation and thereby facilitates the removal of intron 2 of dishevelled segment polarity protein 2 (DVL2) pre-mRNA; thereby augmenting Wnt/β-catenin signalling and tumorigenesis.