Xu et al. demonstrated that lncRNA SNHG1 directly interacts with the EZH2 subunit of Polycomb Repressive Complex 2 (PRC2) and modulates histone methylation of Kruppel like factor 2 (KLF2) and CDKN2B promoters in CRC [74]. This evidence concerns the gene KLF2 and colorectal carcinoma.