PTBP2 and colorectal carcinoma: Another study found that MALAT1 promotes tumour growth and metastasis in CRC by competitively binding to SFPQ (also known as Polypyrimidine Tract-Binding Protein-associated splicing factor) and releasing oncogene PTBP2 (polypyrimidine tract binding protein 2) from the SFPQ/PTBP2 complex [143].