During the early stages of CRC development, the normal colorectal epithelium is transformed into a benign adenoma by inactivation mutations in tumour suppressor genes (e.g., APC, TP53, SMAD4) and activating mutations in proto-oncogenes (KRAS, BRAF, PIK3CA) [1,15,16]. This evidence concerns the gene PIK3CA and colorectal carcinoma.