Wang et al. [76] investigated the mechanism behind melittin antitumor activity and showed that melittin can induce apoptosis of hepatocellular carcinoma cells (HCC) through the activation of the CAMKII-TAK1-JNK/p38 signaling pathway (CAMKII: Ca2+/calmodulin-dependent protein kinase; TAK1: Transforming growth factor-beta-activated kinase 1; JNK/p38: Mitogen-activated protein kinases). This evidence concerns the gene WNK2 and hepatocellular carcinoma.