Low PBRM1 expression has been shown to predict poor prognosis in breast cancer and mutations in PBRM1 have been reported in many tumor types such as renal cell carcinoma, biliary carcinoma, gallbladder carcinoma, and intrahepatic cholangiocarcinoma [28,40]. The gene discussed is PBRM1; the disease is hereditary clear cell renal cell carcinoma.