Further analyses revealed that 10 differentially expressed genes are possibly instrumental in asthma, including up-regulated CEACAM5, CLCA1, POSTN, CPA3, SERPINB2, KRT6A, CD44, MUC5AC, and down-regulated LTF and MUC5B. Especially, the present study suggests that CD44, KRT6A, LTF, SERPINB2, MUC5B, and CEACAM5 could serve as hub genes in asthma-relevant PPI network and could further act as the biomarkers of asthma. The gene discussed is CD44; the disease is asthma.