ACE and hypertensive disorder: Nevertheless the risk allele for hypertension indicated by robust metanalysis studies point out the D allele (or DD genotype)[16] of ACE I/D polymorphism; while for ACE2 G8790A polymorphism the findings are more controversial with the great majority of the studies conducted in China been pointed out the A allele (or AA genotype) as the susceptibility profile [33,34].