In another Brazilian study, Sakuma et al. (2004) [26] have evaluated ACE I/D polymorphism association with coronary artery disease in hypertensive and normotensive African-Brazilian subjects from a state of the Central Brazil region (Mato Grosso do Sul) and they have obtained allelic frequencies very close to the observed in this study (around 50% for each allele). Here, ACE is linked to coronary artery disorder.