Spleen cT1 (p = 0.014), liver cT1 (p = 0.032), Ishak stage (p = 0.038) and AST/ALT ratio (p = 0.064) and prothrombin time (p = 0.065) were all predictors of clinically significant portal hypertension with p<0.1. This evidence concerns the gene F2 and portal hypertension.