Animal models for α- and δ-sarcoglycanopathies [B6.129S6-Sgcatm2Kcam/J (Sgca-/-; LGMD2D) and B6.129-Sgcdtm1Mcn/J (Sgcd-/-; LGMD2F) mice, respectively] have been generated mimicking many features of the human disease [8, 9]. Here, SGCA is linked to autosomal recessive limb-girdle muscular dystrophy type 2D.