In previous studies IL‐2 has been shown to enhance diagnosis of LTBI, particularly in those with borderline QFT results.19 In addition, IL‐2 levels are generally higher in LTBI compared with active TB patients.20 Our results showing elevation of IL‐2 before IFN‐γ conversion by QFT suggests IL‐2 is a likely marker of early infection leading to subsequent conversion. The gene discussed is IFNG; the disease is infection.