NF‐κB signalling is associated with numerous of cellular responses, such as cell survival, differentiation and proliferation.25 NF‐κB signalling has been reported to play an vital role in malignant cell mobility.34, 35 Recent studies showed ANXA2 could mediate upregulation of NF‐κB.26, 27 It is possible that S100A11 may promote GBM progression via regulating ANXA2‐mediated NF‐κB pathway. Here, NFKB1 is linked to glioblastoma.