ANXA2 is a calcium‐dependent phospholipid‐binding protein.33 ANXA2 is overexpressed in various tumours, including breast cancer, pancreatic cancer, ESCC and glioma, which plays important roles in tumour progression by regulating cell growth, apoptosis, invasion and tumour neovascularization.14 Calcium can trigger S100A11‐ANXA2 interaction in repair cell membrane.22 It is possible that S100A11 could interact with ANXA2 to promote the progression of GBM. This evidence concerns the gene ANXA2 and central nervous system cancer.