Firstly, we examined the expression of S100 family in GBM from TCGA database, we found that S100A2, S100A3, S100A6, S100A10, S100A11, S100A16 and S100PBP were up‐regulated in GBM tissues compared with NBTs (Figure 1A). This evidence concerns the gene S100A3 and glioblastoma.