Firstly, we examined the expression of S100 family in GBM from TCGA database, we found that S100A2, S100A3, S100A6, S100A10, S100A11, S100A16 and S100PBP were up‐regulated in GBM tissues compared with NBTs (Figure 1A). The gene discussed is S100A6; the disease is glioblastoma.