Annexins and S100 proteins are two large but distinct calcium‐binding protein families.22 S100 proteins can interact with some annexins, such as ANXA1 and ANXA2.22 Ca2+ can trigger S100A11‐ANXA2 interaction.22 Additionally, ANXA2 promotes glioma cell invasion and tumour progression. Here, ANXA2 is linked to neoplasm.