GAD1 and depressive disorder: NAc is considered as a neural interface between motivation and action, which is characteristically disrupted in major depression disorders,12, 13, 14, 15 as well as for the depression‐related GABAergic deficits.16, 17, 18 The GABA release associated genes and proteins (Gad‐1, VGAT and GAT‐3) in the NAc tissue were detected by qRT‐PCR and Western blotting (WB).