This miRNA family also can target the 3’ UTR of BDNF, cholinergic receptor, muscarinic 1 and methyl‐CpG binding protein 1.51, 52 All of these targetings have been confirmed in the process of depression pathophysiological mechanism.53 These data provided evidence that the miR‐15 family played an important role in the pathogenesis of depression by mediating GABA release and uptake. This evidence concerns the gene BDNF and depressive disorder.