At 6 years old: 86cm (SDS), 10kg and BA= 3years. Length at preterm birth (28 weeks) =39cm and Weight= 1.7kg. Milddysmorphic features, atopic eczema, interstitial lung disease,hyperprolactinemia. GH peak =20.6mcg/L, IGF1=34ng/mL. Treatment with GHwhithout clear improvement. This evidence concerns the gene IGF1 and atopic eczema.