In the present work, the study of the COL1A1, COL1A2,P3H1, FKBP10 and IFITM5 genes,selected from among 20 other distinct genes that can cause OI, allowed the detectionof genetic changes in at least 95% of our subjects, providing supporting to thehypothesis that these genes contain most of the mutations found among OI patients.We failed to identify mutations in one patient. Here, COL1A1 is linked to osteogenesis imperfecta.