While this SNP has been identified in the context of a study evaluating how inherited polymorphisms carried in the germline affect the somatic evolution of a tumor, it will be important to study whether this SNP has other effects on cognitive brain functions and leads to an increase in the incidence of neurodegenerative disorders where TrkB.T1 upregulation has also been reported (Cai et al., 2006; Dwivedi et al., 2003; Ernst et al., 2009b; Karege et al., 2005a; Karege et al., 2005b). This evidence concerns the gene NTRK2 and neoplasm.