BDNF and Intellectual disability: Although alterations in BDNF signaling caused by disruptions in its expression or changes in levels of Ntrk2 receptor isoforms have been associated with neurodegeneration, psychiatric disorders, intellectual disabilities and autism, most studies have focused on the mechanisms regulating Bdnf expression and not its receptor TrkB (Qin et al., 2016; Zheng et al., 2016).