Taken together, these results suggest that overexpression of YAP/TAZ increases CCN1 expression and secretion from cancer cells into the tumour microenvironment, which activates tip cell activity by increasing the expression of YAP/TAZ as well as VEGFR2 and DLL4 in ECs to promote vascular sprouting and tumour angiogenesis. This evidence concerns the gene WWTR1 and neoplasm.