In addition, reactivation of Hippo pathway in several cancers on inhibition of integrin linked kinase (Serrano et al., 2013) and repressed CCN1 on targeted inhibition of integrin αvβ3 suppressing the metastasis in osteosarcoma (Gvozdenovic et al., 2016) suggested interplay of integrin αvβ3 and Hippo signalling but this is the first time to show the CCN1 mediated feedback loop through integrin αvβ3/YAP/TAZ axis in vascular sprouting. This evidence concerns the gene CCN1 and osteosarcoma.