WWTR1 and neoplasm: In growth factor-mediated YAP signalling via the MAPK and PI3K nexus, large tumour suppressor kinase 1 (LATS1), a tumour suppressor that phosphorylates YAP/TAZ, is repressed through reduced phosphorylation, thus enhancing the nuclear localization of YAP (Gumbiner and Kim, 2014; Kim and Gumbiner, 2015).