As we previously reported [3], α-SMA siRNA had a greater effect on small capillaries (< 7 μm) and prevented ischemia-induced diameter decrease in these capillaries (scrambled siRNA pre-treatment + ischemia: 4.07 ± 0.12 μm, 88 vessels; α-SMA siRNA + ischemia: 4.52 ± 0.12 μm, 92 vessels; P = 0.01, Student’s t-test). This evidence concerns the gene ACTA1 and ischemia.