Cytolytic-low (but not high) colon adenocarcinomas had recurrent deletions at loci important in COAD, including 4q28.3 (NFKB1, RHOH), 5q21.3 (APC), 8p23.1 (SOX7), 10q22.1 (SIRT1), 16p13.3 (RBFOX1), 17p13.1 (TP53), 15q22.31 (SMAD6), 18q21.2 (DCC), and amplifications in 5q23.1 (ATG12), 8p11.21 (ZMAT4), 8q24.21 (POU5F1B), 11p15.5 (IGF2), 13q12.13 (GTF3A), 13q21.33 (KLF5), 17p11.2 (KCNJ12), among other alterations. Here, SIRT1 is linked to colon adenocarcinoma.