To verify this assumption, we conducted OncodriveCLUST analysis [42] and identified a single significant BRAF mutation cluster among CYT-high colon tumors; whereas, in the CYT-low subgroup we detected different drivers, including TP53, KRAS, PCBP1 (all of them with one mutation cluster) and FBXW7, with three mutation clusters (Fig. 3g). The gene discussed is BRAF; the disease is colonic neoplasm.