Several other immune-related molecules, including IL2RB, TRGV10, TIGIT, CCL5, TRGC2, CD96, HLA-DRA, CD8A, GZMH, TRG-AS1, FASLG, and NKG7 were included within the top-upregulated genes in the CYT-high subgroups in both datasets, clarifying their involvement in the tumor microenvironment (Additional file 15: Table S6). This evidence concerns the gene TIGIT and neoplasm.