The expression of several immune checkpoints, including VTCN1, VISTA, HAVCR2, IDO1/2, PD-1, PD-L1, and CTLA-4, was also significantly elevated in the CYT-high subgroup of COAD and READ tumors (Fig. 2e-f). The gene discussed is HAVCR2; the disease is colon adenocarcinoma.