SMAD6 and colon adenocarcinoma: Cytolytic-low (but not high) colon adenocarcinomas had recurrent deletions at loci important in COAD, including 4q28.3 (NFKB1, RHOH), 5q21.3 (APC), 8p23.1 (SOX7), 10q22.1 (SIRT1), 16p13.3 (RBFOX1), 17p13.1 (TP53), 15q22.31 (SMAD6), 18q21.2 (DCC), and amplifications in 5q23.1 (ATG12), 8p11.21 (ZMAT4), 8q24.21 (POU5F1B), 11p15.5 (IGF2), 13q12.13 (GTF3A), 13q21.33 (KLF5), 17p11.2 (KCNJ12), among other alterations.