PIK3CD and colonic neoplasm: Cytolytic-high colon tumors on the other hand, were characterized by recurrent deletions at loci 1p35.3 (PIK3CD, TP73, miR34a), 6p25.3 (FOXC1), and 21q11.1 (Let-7c), and amplifications at loci 8q24.21 (MYC) and 20q13.12 (MMP9) (Fig. 5a-c and Additional file 16: Table S7).