We further investigated mutually exclusive or co-occurring gene sets in each dataset, and found that BRAF was mutually exclusive with APC in COAD, while a broad combination of significant co-occurrences was scored between other gene pairs in both datasets, including FBXW7 and MUC16 (Additional file 5: Figure S5). The gene discussed is FBXW7; the disease is colon adenocarcinoma.