HSPG2 and cirrhosis of liver: Several frequently mutated genes were found to be associated mainly with worse prognosis with higher tumor grades (FRG1, FRG1B), later stage (UTRN), tumor necrosis (HSPG2), liver cirrhosis (GANC), larger tumor size (WASH1) and worse overall survival (KIF21A and LSS), although mutations in ABCA2 and ITSN2 were associated with better prognosis with no liver cirrhosis and no tumor invasion, respectively.