MECP2 and central nervous system cancer: To explore whether MeCP2 represses the level of miR-200c expression via H3K9me3 modification in glioma cells, and the results found that a significant enrichment of H3K9me3 in the miR-200c promoter was observed in MeCP2-overexpressed glioma cells compared with vector cells (Fig. 8a-c).