Hence in this study, we established a HFpEF pig model with a combination of deoxycorticosterone acetate (DOCA), angiotensin II (Ang II) and Western diet (WD) feeding, that manifests major features of clinical HFpEF patients to a large extent [6, 8, 23], to investigate the therapeutic effects of dapagliflozin on blood pressure, hyperlipidemia, and cardiac structure and function, as well as its potential related molecular mechanisms in HFpEF. Here, AGT is linked to hyperlipidemia.