The results of other studies demonstrated that LINC00460 exerts its oncogenic effects via the LINC00460/EZH2/KLF2 signaling axis in colorectal cancer cells [23] and showed that CBP/P300 binds to the LINC00460 promoter to activate LINC00460 transcription via histone acetylation to promote carcinogenesis in esophageal cancer cells [21]. The gene discussed is KLF2; the disease is colorectal cancer.