IL1RAP and chronic myelogenous leukemia, BCR-ABL1 positive: Another iCasp9 engineered CAR-T cells targeting interleukin-1 receptor accessory protein (IL-1RAP) which is expressed by chronic myeloid leukemia (CML) but not the normal CD34+ hematopoietic stem cell [61] showed cytotoxicity against IL-1RAP-positive cell lines or primary CML cells and induced secretion of pro-inflammatory cytokines in vitro and in vivo.