The purinergic receptor P2Y1 (P2RY1) was down-regulated in LUAD but up-regulated in LUSC, according to our study and also identified as a possible LUSC oncogene by Moonlight. Of note, its levels can be regulated by the miR-34b-3p microRNA in bladder cancer [86]. The gene discussed is P2RY1; the disease is urinary bladder cancer.