Atherosclerosis is generally considered to be the pathological foundation of CAD [6] and ischemic stroke [7], which is caused by the accumulation of cholesterol in arterial wall macrophages and the dysregulation of metabolic rate of lipids for example increased levels of low-density lipoprotein cholesterol (LDL-C) [8], and apolipoprotein (Apo) B [9], triglyceride (TG) [10], total cholesterol (TC) [11], along with reduced levels of high-density lipoprotein cholesterol (HDL-C) [12] and ApoA1 [9] in serum. The gene discussed is APOB; the disease is ischemic stroke.