In another study, adults with IgG2/IgA deficiency had no IgG response to PPSV14 In normal adults, the predominant PPSV14 response occurred in IgG2 subclass [10], although PPSV14 responses also occur in other IgG subclasses [62]. This evidence concerns the gene CD79A and hyperinsulinemic hypoglycemia, familial, 4.