Circular RNA products were discovered to originate from the ANRIL locus, and the causal variants at 9p21.3 regulated INK4/ARF expression and influenced atherosclerotic vascular disease risk by modulating ANRIL expression and structure.35 Khan MA et al36 reported that several circRNAs expressed from the titin locus gene were dynamically regulated in dilated cardiomyopathy. The gene discussed is TTN; the disease is dilated cardiomyopathy.