NSUN5 and central nervous system cancer: Multivariate Cox regression analysis showed that NSUN5 hypermethylation was an independent predictor of OS in the TCGA glioma cohort (HR = 0.50; 95% CI = 0.26–0.94; P = 0.032) (Fig. 8a) and an independent predictor of PFS in the interrogated validation cohort of glioma patients (HR = 0.46; 95% CI = 0.35–0.61; P < 0.001) (Fig. 8b).