NSUN5 and cancer: To identify candidate genetic and epigenetic defects in the proposed ribosomal RNA cytosine methyltransferases NSUN5, NSUN1 (28S rRNA C4447), and NSUN4 (12S mitochondrial rRNA C841) in human tumorigenesis, we first data-mined a collection of 1001 human cancer cell lines in which we had recently determined the exome mutational, transcriptomic, gene copy number, and DNA methylation profiles [20].