Beyond glioma-derived malignancies, the NSUN5 promoter CpG island was mostly found to be unmethylated in the other tumor types available in our data set, with the exception of thyroid cancer (4 of 16, 25%), biliary tract (1 of 5, 20%), autonomic ganglia (6 of 33, 18%), and soft-tissue sarcoma (3 of 23, 13%) (Fig. 1a and Suppl. Here, NSUN5 is linked to neoplasm.