NSUN5 hypermethylation was associated with higher OS in LGG (log-rank; P = 0.044; HR = 2.05; 95% CI = 1.01–4.18) and GBM (log-rank; P = 0.012; HR = 8.26; 95% CI = 1.15–59.50) (Fig. 7c). This evidence concerns the gene NSUN5 and glioblastoma.