NQO1 and central nervous system cancer: The use of the NQO1 bioactivatable substrate increased survival in those nude mice with tumors originated from NSUN5 hypermethylated A127 glioma cells in comparison with the mock-treated group (Fig. 6f), whereas no differences in survival between drug and mock treatment were observed for mice carrying tumors derived from the NSUN5 unmethylated cell line DBTRG-05MG (Fig. 6f).