Beyond glioma-derived malignancies, the NSUN5 promoter CpG island was mostly found to be unmethylated in the other tumor types available in our data set, with the exception of thyroid cancer (4 of 16, 25%), biliary tract (1 of 5, 20%), autonomic ganglia (6 of 33, 18%), and soft-tissue sarcoma (3 of 23, 13%) (Fig. 1a and Suppl. This evidence concerns the gene NSUN5 and central nervous system cancer.