Interestingly, in X-linked dyskeratosis congenita (X-DC), another syndrome related to increased cancer risk, the main mutated gene is DKC1 [18], a pseudouridine synthase that modifies ribosomal RNA (rRNA) at the post-transcriptional level [37, 53]. The gene discussed is DKC1; the disease is dyskeratosis congenita, X-linked.