NSUN5 methylation is associated with extended PFS in low-grade gliomas (LGG, n = 183) (log-rank; P value 10−5; HR = 5.07; 95% CI = 3.46–7.41) (Fig. 7e) and glioblastoma (GBM, n = 235) (log-rank; P value 10−5; HR = 2.14; 95% CI = 1.58–2.91) (Fig. 7e). This evidence concerns the gene NSUN5 and central nervous system cancer.