Among the compression-upregulated metabolic genes, the expression of ENO2 gene was significantly and positively correlated with COL3A1 and HAS1 genes, whereas PFKFB3 genes were significantly and positively correlated with that of COL1A1, HAS2, and HAS3 genes in breast cancer patient tissues (Fig. 7a). Here, PFKFB3 is linked to breast cancer.