Second, albeit PALB2 gene promoter methylation was reported in two of eight inherited breast cancers and four of 60 sporadic breast cancers,13 this phenomenon appears to be vanishingly rare in PALB2-associated breast cancers with mono-allelic PALB2 alterations.12 Further analyses are warranted to define whether other mechanisms of inactivation of the wild-type allele of PALB2 may play a role in PALB2-associated breast cancers with mono-allelic PALB2 alterations but with genomic features of HRD. The gene discussed is PALB2; the disease is breast cancer.