Moreover, in PALB2-associated breast cancers analyzed by WES and harboring indels (n = 14), the average deletion length was significantly longer in cases with bi-allelic PALB2 inactivation (n = 11) as compared to those with mono-allelic alterations (n = 3; 7 bp vs. 2.3 bp; P = 0.041; Fig. 3c), a feature associated with HRD.25 We further found a significantly higher number of copy number alterations (CNAs) in the tumors with bi-allelic PALB2 inactivation (n = 12) than in those without (n = 4; P = 0.004; Fig. 3d). Here, PALB2 is linked to breast cancer.