Moreover, LST score, mutational signature 3, NtAI score and Myriad score detected bi-allelic inactivation of PALB2 and of BRCA1/BRCA2 in PALB2-associated breast cancers and in BRCA1/2-associated breast cancers, respectively, with comparable accuracy (Supplementary Figs. 6d–6g). Here, BRCA1 is linked to breast cancer.