BRCA1 and breast cancer: Consistent with these findings, LST score, NtAI score,26 which assesses telomeric allelic imbalance, and the Myriad score,26 which is the unweighted sum of LOH, telomeric allelic imbalance and LSTs, were higher in breast cancers with PALB2 (n = 12) and BRCA1/2 (n = 33) biallelic inactivation, compared to those with PALB2 (n = 4) and BRCA1/2 (n = 8) monoallelic inactivation, respectively (Supplementary Figs. 6a–6c).