No significant difference in the frequency of amplifications and homozygous deletions was found between the 16 PALB2-associated breast cancers and the 17 BRCA1-associated and 16 BRCA2-associated breast cancers with bi-allelic inactivation of the respective wild-type allele (Supplementary Fig. 5c, d). This evidence concerns the gene BRCA2 and breast carcinoma.