BRCA1 and breast cancer: Our WES findings are consistent with the pan-cancer WES analysis performed by Riaz et al.,15 whereby HR-related genes with bi-allelic inactivation but not those with mono-allelic alterations were found to display genomic features of HRD, and the analyses performed by Polak et al.,24 where bi-allelic, but not mono-allelic, alterations affecting BRCA1, BRCA2, and PALB2 were found to be associated with HRD in breast cancers.