PALB2 and breast cancer: Contrary to that study,12 in which PALB2-associated breast cancers with either mono-allelic or bi-allelic PALB2 alterations were found to display genomic features of HRD, based on targeted massively parallel sequencing of 487 genes, our WES analysis of 16 PALB2-associated breast cancers revealed that tumors with PALB2 bi-allelic alterations displayed significantly higher LST scores and average deletion lengths than PALB2-associated breast cancers with mono-allelic PALB2 alterations.