When compared with OA SFs, genes related to antigen processing and presentation, cytokine-cytokine receptor interaction, and focal adhesion were enriched in RA SFs in states 1, 2, and 3, and the WNT signaling pathway and the TGF-β signaling pathway were enriched in RA in states 1 and 2 (Supplementary Figure 4B). Here, TGFB1 is linked to rheumatoid arthritis.