The relationship of adiponectin to aldosterone appears to be polar opposite in HFpEF, as adiponectin deficiency in a preclinical model of hypertension-associated HFpEF where aldosterone is elevated, exacerbated cardiac remodeling, diastolic dysfunction and pulmonary congestion (74); and adiponectin overexpression protected against the progression of HFpEF by regulating oxidative stress and modulating calcium-handling proteins, specifically cAMP-dependent protein kinase (PKA) phosphorylation of phospholamban (75). This evidence concerns the gene ADIPOQ and hypertensive disorder.