THY1 and melanoma: Additionally, Thy-1/CD90 expressed in activated endothelial cells at sites of inflammation binds to monocytes, leukocytes, and melanoma cells through various integrins, such as αVβ3, αXβ2, or αMβ2 integrins (Wen et al., 2013) and also via the seven-transmembrane protein CD97, possibly to allow trans-endothelial migration of these cells (Ward et al., 2018).