In lung fibrosis, Thy-1/CD90 associates with αvβ5 integrin in cis, promoting the inhibition of latent TGF-β1 activation induced by myofibroblast contraction, likely by competing with the RGD motifs on the N-terminal latency-associated peptide (LAP) and those of ECM proteins (Zhou et al., 2010). This evidence concerns the gene THY1 and pulmonary fibrosis.