While canonical autophagy may target Salmonella at later stages of infection, we found that the initial Lc3 response to Salmonella is independent of the autophagy pre-initiation factor Atg13, which led us to conclude that LAP is the major autophagic pathway involved in the anti-Salmonella reaction under conditions where macrophages dominate the defense response (Masud et al., 2019). The gene discussed is MAP1LC3A; the disease is infection.