SPI1 and Salmonella Infections: Many SPI-1 effector proteins have been identified in Salmonella. These effectors play a variety of roles during Salmonella infection, including taking part in rearrangement of the host cytoskeleton, immune cell recruitment, cell metabolism, fluid secretion, and regulation of the host inflammatory response (Collier-Hyams et al., 2002; Brawn et al., 2007; Myeni et al., 2013).